The PhD researcher Songbai Zhang, from the Molecular Nanoscience and Organic Materials (NANOMOL) Group at ICMAB-CSIC, will defend his PhD thesis on Tuesday 23 November 2021 at 11:00 am in a hybrid session.
By Songbai Zhang, from the Molecular Nanoscience and Organic Materials (NANOMOL) Group at ICMAB-CSIC
Date: Tuesday 23 November 2021
Time: 11:00 am
Venue: ICMAB Seminar Room "Carles Miravitlles" and online session by Zoom. Register here to attend by Zoom.
Abstract: In this Thesis we have developed metal-free contrast agents (CAs) for magnetic resonance imaging (MRI) applications to overcome the established toxicity of the most widely used CAs in clinical diagnosis based on Gd(III) complexes. Our strategy is the incorporation of many persistent organic radicals to a dendrimer scaffold, obtaining the so-called ‘radical dendrimers’. Dendrimers are monodisperse polymers with a well-defined molecular structure, that provides a shield effect protection to the radicals. Different water-soluble radical dendrimers systems have been developed showing good relaxivities and low cytotoxicity. Furthermore, bimodal CAs for potential MRI and fluorescence imaging applications has been proposed. Finally, in vivo studies have been performed to determine the suitability of radical dendrimers as MRI contrast agents.
University: Universitat Autònoma de Barcelona
PhD Programme: Chemistry