Bioactive materials for therapy and diagnosis

Limbal Stem Cells on Bacterial Nanocellulose Carriers for Ocular Surface Regeneration

Autores: Irene Anton‐Sales, Laura Koivusalo, Heli Skottman, Anna Laromaine, Anna Roig
Citation: Small 2021, 2003937
DOI: https://doi.org/10.1002/smll.202003937
PlumX: Limbal Stem Cells on Bacterial Nanocellulose Carriers for Ocular Surface Regeneration
Limbal stem cells (LSCs) are already used in cell‐based treatments for ocular surface disorders. Clinical translation of LSCs‐based therapies critically depends on the successful delivery, survival, and retention of these therapeutic cells to the desired region. Such a major bottleneck could be overcome by using an appropriate carrier to provide anchoring sites and structural support to LSC culture and transplantation.

Biomaterials

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Impact of Chemical Composition on the Nanostructure and Biological Activity of α-Galactosidase-Loaded Nanovesicles for Fabry Disease Treatment

Título : Impact of Chemical Composition on the Nanostructure and Biological Activity of α-Galactosidase-Loaded Nanovesicles for Fabry Disease Treatment
Autores: Judit Tomsen-Melero, Solène Passemard, Natalia García-Aranda, Zamira Vanessa Díaz-Riascos, Ramon González-Rioja, Jannik Nedergaard Pedersen, Jeppe Lyngsø, Josep Merlo-Mas, Edgar Cristóbal-Lecina, José Luis Corchero, Daniel Pulido, Patricia Cámara-Sánchez, Irina Portnaya, Inbal Ionita, Simó Schwartz Jr., Jaume Veciana, Santi Sala, Miriam Royo, Alba Córdoba, Dganit Danino, Jan Skov Pedersen, Elisabet González-Mira*, Ibane Abasolo*, and Nora Ventosa*
Citation:
ACS Appl. Mater. Interfaces 2021, XXXX, XXX, XXX-XXX
Publication Date:February 14, 2021
DOI: https://doi.org/10.1021/acsami.0c16871
PlumX: Impact of Chemical Composition on the Nanostructure and Biological Activity of α-Galactosidase-Loaded Nanovesicles for Fabry Disease Treatment
Fabry disease is a rare lysosomal storage disorder characterized by a deficiency of α-galactosidase A (GLA), a lysosomal hydrolase. The enzyme replacement therapy administering naked GLA shows several drawbacks including poor biodistribution, limited efficacy, and relatively high immunogenicity in Fabry patients.An attractive strategy to overcome these problems is the use of nanocarriers for encapsulating the enzyme. Nanoliposomes functionalized with RGD peptide have already emerged as a good platform to protect and deliver GLA to endothelial cells.

Biomaterials

  • Hits: 230

Radiolabeled Cobaltabis(dicarbollide) Anion–Graphene Oxide Nanocomposites for In Vivo Bioimaging and Boron Delivery

Autores: Albert Ferrer-Ugalde, Stefania Sandoval, Krishna Reddy Pulagam, Amanda Muñoz-Juan, Anna Laromaine, Jordi Llop, Gerard Tobias*, and Rosario Núñez*
Citation:
ACS Appl. Nano Mater. 2021, XXXX, XXX, XXX-XXXPublication DateJanuary 28, 2021
DOI: https://doi.org/10.1021/acsanm.0c03079
PlumX: Radiolabeled Cobaltabis(dicarbollide) Anion–Graphene Oxide Nanocomposites for In Vivo Bioimaging and Boron Delivery
A carbon-based hybrid nanocomposite, which consists of monoiodinated boron-cluster derivatives covalently attached to graphene oxide, is hereby introduced. This GO-I-COSAN has been synthesized using a novel boron-rich cobaltabis(dicarbollide) precursor with one iodide group attached to one of the boron atoms of the cluster (I-COSAN) and designed to be subsequently labeled with radioactive 124I for its use in positron emission tomography (PET).

Biomaterials

  • Hits: 262

Characterization of crystalline forms of gaxilose, a diagnostic drug

Autores: Federica Cattia, Santos Hernández Gallego, Mónica Benito, Elies Molins, Francisco Marquillas Olóndriz
Citation: Carbohydrate Research
Volume 499, 2021, 108232, ISSN 0008-6215,
DOI: https://doi.org/10.1016/j.carres.2021.108232
PlumX: Characterization of crystalline forms of gaxilose, a diagnostic drug
Lactose intolerance is a pathology caused by lactase enzyme deficiency, usually produced in the intestinal cells provoking symptoms as abdominal pain, bloating, diarrhea, gas and nausea. Gaxilose, 4-O-β-D galactopyranosyl-d-xylose, is used as a diagnostic drug for a non-invasive method for hypolactasia diagnosis.

Biomaterials

  • Hits: 257

Nanostructure ITO and Get More of It. Better Performance at Lower Cost

Autores: Manel López,*, Juan Luis Frieiro, Miquel Nuez-Martínez, Martí Pedemonte, Francisco Palacio and Francesc Teixidor,*
Citation: Nanomaterials 202010(10), 1974
DOI: https://doi.org/10.3390/nano10101974
PlumX: Nanostructure ITO and Get More of It. Better Performance at Lower Cost

In this paper, we investigated how different growth conditions (i.e., temperature, growth time, and composition) allows for trading off cost (i.e., In content) and performance of nanostructured indium tin oxide (ITO) for biosensing applications. Next, we compared the behavior of these functionalized nanostructured surfaces obtained in different growth conditions between each other and with a standard thin film as a reference, observing improvements in effective detection area up to two orders of magnitude. This enhanced the biosensor’s sensitivity, with higher detection level, better accuracy and higher reproducibility.

Biomaterials

  • Hits: 413

Sunitinib-Containing Carborane Pharmacophore with the Ability to Inhibit Tyrosine Kinases Receptors FLT3, KIT and PDGFR-β, Exhibits Powerful In Vivo Anti-Glioblastoma Activity

Título : Sunitinib-Containing Carborane Pharmacophore with the Ability to Inhibit Tyrosine Kinases Receptors FLT3, KIT and PDGFR-β, Exhibits Powerful In Vivo Anti-Glioblastoma Activity
Autores: Catalina Alamón, Belén Dávila, María Fernanda García, Carina Sánchez, Mariángeles Kovacs, Emiliano Trias, Luis Barbeito, Martín Gabay, Nidal Zeineh, Moshe Gavish, Francesc Teixidor, Clara Viñas,*,Marcos Couto,* and Hugo Cerecetto,*
Citation: Cancers 202012(11), 3423
DOI: https://doi.org/10.3390/cancers12113423
PlumX: Sunitinib-Containing Carborane Pharmacophore with the Ability to Inhibit Tyrosine Kinases Receptors FLT3, KIT and PDGFR-β, Exhibits Powerful In Vivo Anti-Glioblastoma Activity

Malignant gliomas are the most common malignant and aggressive primary brain tumors in adults, the prognosis being—especially for glioblastomas—extremely poor. There are no effective treatments yet. However, tyrosine kinase receptor (TKR) inhibitors and boron neutron capture therapy (BNCT), together, have been proposed as future therapeutic strategies. In this sense in our ongoing project of developing new anti-glioblastoma drugs, we identified a sunitinib-carborane hybrid agent, 1, with both in vitro selective cytotoxicity and excellent BNCT-behavior.

Biomaterials

  • Hits: 391

Nanorods Based on Mesoporous Silica Containing Iron Oxide Nanoparticles as Catalytic Nanomotors: Study of Motion Dynamics

Autores: Rafael Mestre, Núria Cadefau, Ana C. Hortelão, Jan Grzelak, Dr. Martí Gich, Prof. Anna Roig, Prof. Samuel Sánchez
Citation: ChemNanoMat
DOI: https://doi.org/10.1002/cnma.202000557
PlumX: Nanorods Based on Mesoporous Silica Containing Iron Oxide Nanoparticles as Catalytic Nanomotors: Study of Motion Dynamics

Self‐propelled particles and, in particular, those based on mesoporous silica, have raised considerable interest due to their potential applications in the environmental and biomedical fields thanks to their biocompatibility, tunable surface chemistry and large porosity. Although spherical particles have been widely used to fabricate nano‐ and micromotors, not much attention has been paid to other geometries, such as nanorods.

Biomaterials

  • Hits: 322

Highlights on the Binding of Cobalta‐Bis‐(Dicarbollide) with Glucose Units

Autores: Tania Merhi, Alban Jonchère, Dr. Luc Girard, Dr. Olivier Diat, Miquel Nuez, Prof. Clara Viñas, Dr. Pierre Bauduin
Citation:

Chem. Eur. J. 2020, 26, 13935
DOI: https://doi.org/10.1002/chem.202002123

PlumX: Highlights on the Binding of Cobalta‐Bis‐(Dicarbollide) with Glucose Units
Metalla‐bis‐dicarbollides, such as the cobalta‐bis‐dicarbollide (COSAN) anion [Co(C2B9H11)2], have attracted much attention in biology but a deep understanding of their interactions with cell components is still missing. For this purpose, we studied the interactions of COSAN with the glucose moiety, which is ubiquitous at biological interfaces.

Biomaterials

  • Hits: 403

Computer simulations of the interaction between SARS-CoV-2 spike glycoprotein and different surfaces

Autores: David C. Malaspina and Jordi Faraudo
Citation: Biointerphases 15, 051008 (2020)
DOI: https://doi.org/10.1116/6.0000502
PlumX: Computer simulations of the interaction between SARS-CoV-2 spike glycoprotein and different surfaces
A prominent feature of coronaviruses is the presence of a large glycoprotein spike protruding from a lipidic membrane. This glycoprotein spike determines the interaction of coronaviruses with the environment and the host. In this paper, we perform all atomic molecular dynamics simulations of the interaction between the SARS-CoV-2 trimeric glycoprotein spike and surfaces of materials.

Biomaterials

  • Hits: 448

Radical Dendrimers Based on Biocompatible Oligoethylene Glycol Dendrimers as Contrast Agents for MRI

Autores: Songbai Zhang, Vega Lloveras, Daniel Pulido, Flonja Liko, Luiz F. Pinto, Fernando Albericio, Miriam Royo, and José Vidal-Gancedo*
Citation:
. 2020 Aug; 12(8): 772
Published online 2020 Aug 14
DOI: 10.3390/pharmaceutics12080772
PlumX: Radical Dendrimers Based on Biocompatible Oligoethylene Glycol Dendrimers as Contrast Agents for MRI
Finding alternatives to gadolinium (Gd)-based contrast agents (CA) with the same or even better paramagnetic properties is crucial to overcome their established toxicity. Herein we describe the synthesis and characterization of entirely organic metal-free paramagnetic macromolecules based on biocompatible oligoethylene glycol dendrimers fully functionalized with 5 and 20 organic radicals (OEG Gn-PROXYL (n = 0, 1) radical dendrimers) with the aim to be used as magnetic resonance imaging (MRI) contrast agents.
  • Hits: 390

Bimodal Therapeutic Agents Against Glioblastoma, One of the Most Lethal Forms of Cancer

Título : Bimodal Therapeutic Agents Against Glioblastoma, One of the Most Lethal Forms of Cancer
Autores: Dr. Marcos Couto, Catalina Alamón, Susana Nievas, Dr. Marina Perona, Dr. María Alejandra Dagrosa, Prof. Dr. Francesc Teixidor, Prof. Dr. Pablo Cabral, Prof. Dr. Clara Viñas, Prof. Dr. Hugo Cerecetto
Citation: Chem. Eur. J.
doi:10.1002/chem.202002963
PlumX: Bimodal Therapeutic Agents Against Glioblastoma, One of the Most Lethal Forms of Cancer
About 95 % of people diagnosed with glioblastoma die within five years. Glioblastoma is the most aggressive central nervous system tumour. It is necessary to make progress in the glioblastoma treatment so that advanced chemotherapy drugs or radiation therapy or, ideally, two‐in‐one hybrid systems should be implemented.

Biomaterials

  • Hits: 439

3D Reduced Graphene Oxide Scaffolds with a Combinatorial Fibrous-Porous Architecture for Neural Tissue Engineering

Autores: André F. Girão, Joana Sousa, Ana Domínguez-Bajo, Ankor González-Mayorga, Igor Bdikin, Eulalia Pujades-Otero, Nieves Casañ-Pastor, María Jesús Hortigüela, Gonzalo Otero-Irurueta, António Completo, María Concepción Serrano*, and Paula A.A.P. Marques*.
Citation: ACS Appl. Mater. Interfaces 2020, 12, 35, 38962–38975. Publication Date:August 5, 2020. 
https://doi.org/10.1021/acsami.0c10599
PlumX: 3D Reduced Graphene Oxide Scaffolds with a Combinatorial Fibrous-Porous Architecture for Neural Tissue Engineering

Graphene oxide (GO) assists a diverse set of promising routes to build bioactive neural microenvironments by easily interacting with other biomaterials to enhance their bulk features or, alternatively, self-assembling toward the construction of biocompatible systems with specific three-dimensional (3D) geometries.

Biomaterials

  • Hits: 617

Tris-pyridylmethylamine (TPMA) complexes functionalized with persistent nitronyl nitroxide organic radicals

Autores: Elena Badetti,* Vega Lloveras, Francesca Anna Scaramuzzo, Klaus Wurst, Jaume Veciana, José Vidal-Gancedo,* Giulia Licini and  Cristiano Zonta *
Citation: Dalton Trans., 2020,49, 10011-10016
https://doi.org/10.1039/D0DT01553A
PlumX: Tris-pyridylmethylamine (TPMA) complexes functionalized with persistent nitronyl nitroxide organic radicals

The chance to have persistent organic radicals in combination with metals has attracted much interest since it offers the possibility of having new functional molecules with multiple open-shell elements. In this study, we report the synthesis of two tripodal tris(2-pyridyl)methylamine ligands (TPMA) functionalized with nitronyl nitroxide persistent radicals. The newly formed ligands have been used to coordinate zinc(II), copper(II), iron(II) and cobalt(II).

Biomaterials

  • Hits: 635

Nomenclature for boranes and related species (IUPAC Recommendations 2019)

The most recent IUPAC recommendations concerning boron hydrides and related compounds appeared in 2005. These recommendations reinforced earlier IUPAC recommendations in the subject area that had been published in 1990, but was essentially a ‘holding’ chapter, leaving new recommendations for a subsequent edition.

Biomaterials

  • Hits: 482

Dye-Loaded Quatsomes Exhibiting FRET as Nanoprobes for Bioimaging

Fluorescent organic nanoparticles (FONs) are emerging as an attractive alternative to the well-established fluorescent inorganic nanoparticles or small organic dyes. Their proper design allows one to obtain biocompatible probes with superior brightness and high photostability, although usually affected by low colloidal stability.

Biomaterials

  • Hits: 644

Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer’s Disease

Sònia Abás, Sergio Rodríguez-Arévalo, Andrea Bagán, Christian Griñán-Ferré, Foteini Vasilopoulou, Iria Brocos-Mosquera, Carolina Muguruza, Belén Pérez, Elies Molins, F. Javier Luque, Pilar Pérez-Lozano, Steven de Jonghe, Dirk Daelemans, Lieve Naesens, José Brea, M. Isabel Loza, Elena Hernández-Hernández, Jesús A. García-Sevilla, M. Julia García-Fuster, Milica Radan, Teodora Djikic, Katarina Nikolic, Mercè Pallàs, Luis F. Callado, Carmen Escolano*. J. Med. Chem. 2020. Publication Date:March 9, 2020

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