SCIENTIFIC HIGHLIGHTS

Metal–Organic Frameworks Precipitated by Reactive Crystallization in Supercritical CO_sub2sub_
22 May 2017

Fine chemical and pharmaceutical companies often employ reactive crystallization or precipitation to make crystalline intermediates and finished products. In this work, the supercritical reactive crystallization route is used for the precipitation of diverse metal–organic frameworks (MOFs). 1D and 2D MOFs were obtained by reacting either bypyridil (two linking positions) or triazine (three linking positions)-based bridging molecules, respectively, with supercritical CO2 soluble M(hfacac)2 (where M = Zn2+ or Cu2+ and hfacac– stands for hexafluoroacetylacetonate). Additionally, miscellaneous reactions were designed for the crystallization of 3D MOFs in scCO2, embracing the precipitation of MIL-88B(Fe), ZIF-8, and a new Zn2+–curcumin coordination polymer. Obtained crystals in each case were analyzed from a morphological point of view by scanning electron microscopy analysis to elucidate potential formation mechanisms. The focus was on the obtained crystal habits at different reaction points, linked to the precipitation mode and the role of kinetic and thermodynamic crystal growth control. The supercritical procedure led to the crystallization of stable hierarchical nanostructures with micro- and mesoporosity and the precipitation of nanocrystals.

 

Hits: 3779
Bioactive materials for therapy and diagnosis

Metal–Organic Frameworks Precipitated by Reactive Crystallization in Supercritical CO_sub2sub_



Also at ICMAB

  • In vivo soft tissue reinforcement with bacterial nanocellulose

    Information
    11 May 2021 273 hit(s) Biomaterials
    The use of surgical meshes to reinforce damaged internal soft tissues has been instrumental for successful hernia surgery; a highly prevalent condition affecting yearly more than 20 million patients worldwide. Intraperitoneal adhesions between meshes and viscera are one of the most threatening complications, often implying reoperation or side effects such as chronic pain and bowel perforation.
  • Limbal Stem Cells on Bacterial Nanocellulose Carriers for Ocular Surface Regeneration

    Information
    13 April 2021 386 hit(s) Biomaterials
    Limbal stem cells (LSCs) are already used in cell‐based treatments for ocular surface disorders. Clinical translation of LSCs‐based therapies critically depends on the successful delivery, survival, and retention of these therapeutic cells to the desired region. Such a major bottleneck could be overcome by using an appropriate carrier to provide anchoring sites and structural support to LSC culture and transplantation.
  • Impact of Chemical Composition on the Nanostructure and Biological Activity of α-Galactosidase-Loaded Nanovesicles for Fabry Disease Treatment

    Information
    02 April 2021 416 hit(s) Biomaterials
    Fabry disease is a rare lysosomal storage disorder characterized by a deficiency of α-galactosidase A (GLA), a lysosomal hydrolase. The enzyme replacement therapy administering naked GLA shows several drawbacks including poor biodistribution, limited efficacy, and relatively high immunogenicity in Fabry patients.An attractive strategy to overcome these problems is the use of nanocarriers for encapsulating the enzyme. Nanoliposomes functionalized with RGD peptide have already emerged as a good platform to protect and deliver GLA to endothelial cells.
  • Radiolabeled Cobaltabis(dicarbollide) Anion–Graphene Oxide Nanocomposites for In Vivo Bioimaging and Boron Delivery

    Information
    23 March 2021 412 hit(s) Biomaterials
    A carbon-based hybrid nanocomposite, which consists of monoiodinated boron-cluster derivatives covalently attached to graphene oxide, is hereby introduced. This GO-I-COSAN has been synthesized using a novel boron-rich cobaltabis(dicarbollide) precursor with one iodide group attached to one of the boron atoms of the cluster (I-COSAN) and designed to be subsequently labeled with radioactive 124I for its use in positron emission tomography (PET).
  • Characterization of crystalline forms of gaxilose, a diagnostic drug

    Information
    17 March 2021 374 hit(s) Biomaterials
    Lactose intolerance is a pathology caused by lactase enzyme deficiency, usually produced in the intestinal cells provoking symptoms as abdominal pain, bloating, diarrhea, gas and nausea. Gaxilose, 4-O-β-D galactopyranosyl-d-xylose, is used as a diagnostic drug for a non-invasive method for hypolactasia diagnosis.

INSTITUT DE CIÈNCIA DE MATERIALS DE BARCELONA, Copyright © 2020 ICMAB-CSIC | Privacy Policy | This email address is being protected from spambots. You need JavaScript enabled to view it.