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Sunitinib-Containing Carborane Pharmacophore with the Ability to Inhibit Tyrosine Kinases Receptors FLT3, KIT and PDGFR-β, Exhibits Powerful In Vivo Anti-Glioblastoma Activity

Malignant gliomas are the most common malignant and aggressive primary brain tumors in adults, the prognosis being—especially for glioblastomas—extremely poor. There are no effective treatments yet. However, ...

Bimodal Therapeutic Agents Against Glioblastoma, One of the Most Lethal Forms of Cancer

About 95 % of people diagnosed with glioblastoma die within five years. Glioblastoma is the most aggressive central nervous system tumour. It is necessary to make progress in the glioblastoma treatment ...

Discover how ICMAB is helping face cancer on #WorldCancerResearchDay

... and Metallacarboranyl [1,2,3]triazolyl-Decorated Lapatinib-Scaffold for Cancer Therapy Combining Tyrosine Kinase Inhibition and Boron Neutron Capture Therapy Marcos Couto, Catalina Alamón, María Fernanda ...

Closo-Carboranyl- and Metallacarboranyl [1,2,3]triazolyl-Decorated Lapatinib-Scaffold for Cancer Therapy Combining Tyrosine Kinase Inhibition and Boron Neutron Capture Therapy

... Kinase Inhibition and Boron Neutron Capture Therapy Marcos Couto*, Catalina Alamón, María Fernanda García, Mariángeles Kovacs, Emiliano Trias, Susana Nievas, Emiliano Pozzi, Paula Curotto, Silvia Thorp, ...

Viñas Teixidor, Clara [Research Professor]

Carboranylanilinoquinazoline EGFR-inhibitors: toward ‘lead-to-candidate’ stage in the drug-development pipeline

Marcos Couto, Catalina Alamón, Carina Sánchez, Belén Dávila, Marcelo Fernández, Nicole Lecot, Pablo Cabral, Francesc Teixidor, Clara Viñas & Hugo Cerecetto. FUTURE MEDICINAL CHEMISTRY. Vol. 11, No. 17. ...

Discovery of Potent EGFR Inhibitors through the Incorporation of a 3D-Aromatic-Boron-Rich-Cluster into the 4-Anilinoquinazoline Scaffold: Potential Drugs for Glioma Treatment

Marcos Couto, María Fernanda García, Catalina Alamón, Prof. Mauricio Cabrera, Prof. Pablo Cabral, Prof. Alicia Merlino, Prof. Francesc Teixidor, Prof. Hugo Cerecetto, Prof. Clara Viñas. Chem. Eur. J. doi:10.1002/chem.201705181 ...